Answer: B. Fenofibrate
Fenofibrate is generally the fibrate of choice, when combined with a statin. Gemfibrozil can increase the maximum statin concentration of most agents except fluvastatin. The maximum concentration is generally not affected when statins are combined with fenofibrate.1 In 2013, the American College of Cardiology/American Heart Association made a strong statement against using gemfibrozil with any statin. Clofibrate is similar to gemfibrozil.2
Please click below for answer and next question.
1. Kellick KA, Bottorff M, Toth PP, The National Lipid Association's Safety Task Force. A clinician's guide to statin drug-drug interactions. J Clin Lipidol. 2014;8:S30-46.
2. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol. 2013;63:2889-2934.
3. US Food and Drug Administration. FDA Drug Safety Communication: interaction between certain HIV or hepatitis C drugs and cholesterol-lowering statin drugs can increase the risk of muscle injury. http://www.fda.gov/Drugs/DrugSafety/ucm293877.htm. Published March 1, 2012. Acessed May 8, 2018.
4. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. US Department of Health and Human Services. Available at https://aidsinfo.nih.gov/contentfiles/adultandadolescentgl003093.pdf. Accessed May 18, 2018.