Pulmonary arterial hypertension (PAH) is progressive and evetually results in right ventricular (RV) failure and death. RV function primarily determines prognosis. There are limited clinical measurements available to guide risk stratification for PAH patients.
Pulmonary arterial proportional pulse pressure (PAPP) reflects the RV adaptive response to increased afterload and there is some evidence to suggest that low PAPP is a powerful predictor of poor prognosis in advanced HF.1
The slides that follow summarize a recent study that investigates the use of PAPP as a novel and easily measured index to guide risk stratification in PAH.