The Status of Gene Therapy Development for Retinal Diseases

EP: 1.Impact of First-Line Therapy on Long-Term Outcomes in nAMD and DME

EP: 2.Choosing First-Line Therapy in nAMD or DME

EP: 3.When to Switch to More Efficacious Agents

EP: 4.Real-World Experiences With Faricimab

EP: 5.Real-World Experiences With Aflibercept 8mg

EP: 6.Efficacy and Durability: New Therapies vs Aflibercept 2mg

EP: 7.Perspectives on Retinal Fluid Management

EP: 8.Perspectives on Loading Dose Recommendations for New Therapies

EP: 9.Safety Considerations for New Therapies

EP: 10.The Impact of Biosimilars in Retinal Diseases

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EP: 11.The Status of Gene Therapy Development for Retinal Diseases

EP: 12.Considering Safety of Gene Therapy for Retinal Diseases

EP: 13.Role of Tyrosine Kinase Inhibitors and Gene Therapy in Retinal Diseases

EP: 14.Perspectives on the Future of Retinal Disease Management

Summary

This segment shifts towards the future of retinal therapies, focusing on gene therapy. David Eichenbaum, MD asks Kenny Fan, MD, MBA about his perspective on gene therapy and the status of ongoing trials. Fan expresses optimism and mentions his enthusiasm for gene therapy, particularly due to the promising clinical and preclinical data. He acknowledges that gene therapy has significant potential, not only for age-related macular degeneration (AMD) and diabetes but also for other hereditary retinal diseases. Fan touches on intravitreal gene therapy and subretinal gene therapy, highlighting their potential benefits. He mentions that the initial results from certain gene therapy trials have been optimistic, and he looks forward to more phase 3 data to further assess the impact of gene therapy on retinal diseases. David Eichenbaum, MD adds to the discussion by distinguishing between gene augmentation for common retinal diseases and gene replacement for inherited retinal diseases. The conversation reflects a sense of optimism and hope for the transformative potential of gene therapy in the treatment of retinal diseases.

This summary was AI-generated and edited for clarity.